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- Testosterone alternative in hypogonadal males with angina improves ischaemic threshold and high quality of life.
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- Physicians and sufferers should pay consideration to the medical penalties of anabolic steroid abuse.
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However, testosterone in physiologic doses could even be beneficial in sufferers with angina , have higher ischemic thresholds and improved high quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and increases coronary blood circulate in males with established coronary artery disease . Therefore, an interaction of endogenous elements of the patient’s danger profile as well as the testosterone dosing could additionally be issues of whether opposed events happen. Erythrocytosis has been reported as a potential effect of testosterone, which can be helpful in patients with anemia.
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We report a case of an acute ST-segment elevation myocardial infarction in a patient with traditional cardiac danger factors using supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this patient additionally had polycythemia, doubtless secondary to high-dose testosterone. The patient underwent profitable percutaneous intervention of the right coronary artery. Physicians and patients should be aware of the clinical penalties of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a component of endothelial dysfunction has been proposed, which may contribute to abnormal vessel reactivity.
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Patients additionally may be taking concomitant stimulants, similar to ephedra, which may confound information and the potential for adverse events. It is likely that the frequency of cardiac events is underreported in the medical literature. Moreover, testosterone has been used within the remedy of decreased muscle mass and bone density as properly as anemia. The position testosterone may play in the growth of cardiovascular disease has more and more turn into the topic of present curiosity . Supraphysiologic doses of anabolic-androgenic steroids , which embody greater than 30 pure and artificial derivatives of testosterone, may trigger a large spectrum of clinical sequalae. Supplemental or physiologic doses of testosterone have seen expanded use in medical practice just lately. Other widespread potential antagonistic results embody infertility, hepatotoxicity, psychological abnormalities, and gynecomastia .
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