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- Supraphysiologic doses of anabolic-androgenic steroids , which embrace greater than 30 natural and synthetic derivatives of testosterone, could trigger a wide spectrum of scientific sequalae.
- Men with coronary artery illness have lower levels of androgens than men with regular coronary angiograms.
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Patients also may be taking concomitant stimulants, similar to ephedra, which can confound information and the potential for adverse occasions. It is likely that the frequency of cardiac events is underreported in the medical literature. Moreover, testosterone has been used in the remedy of decreased muscle mass and bone density as properly as anemia. The function testosterone could play in the development of cardiovascular disease has more and more turn out to be the subject of current curiosity . Supraphysiologic doses of anabolic-androgenic steroids , which include more than 30 pure and synthetic derivatives of testosterone, could trigger a wide spectrum of clinical sequalae. Supplemental or physiologic doses of testosterone have noticed expanded use in medical follow recently. Other common potential adverse results embody infertility, hepatotoxicity, psychological abnormalities, and gynecomastia .
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We report a case of an acute ST-segment elevation myocardial infarction in a patient with traditional cardiac threat elements utilizing supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this affected person also had polycythemia, doubtless secondary to high-dose testosterone. The affected person underwent successful percutaneous intervention of the best coronary artery. Physicians and patients should pay attention to the clinical penalties of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a component of endothelial dysfunction has been proposed, which can contribute to irregular vessel reactivity.
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However, testosterone in physiologic doses may even be helpful in sufferers with angina , have higher ischemic thresholds and improved quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and increases coronary blood flow in males with established coronary artery illness . Therefore, an interaction of endogenous factors of the patient’s risk profile as well as the testosterone dosing may be problems with whether or not antagonistic events occur. Erythrocytosis has been reported as a possible impact of testosterone, which could be beneficial in patients with anemia.